There’s been much promise in slowing and preventing the diseases’s progression including interventions and drugs. Researchers began to gather information on people who had Alzheimer’s and found that elderly people with the e4 gene who exercised regularly had significantly more brain activity during cognitive tests than people with the e4 gene who did not exercise, suggesting that the exercisers’ brains were functioning better.
Researchers at the Cleveland Clinic in Ohio recruited almost 100 older men and women, aged 65 to 89, whom had a family history of Alzheimer’s disease. Researchers asked their volunteers how often and how intense they exercised. About half walked, jogged or exercised very moderately during the week, and the other half didn’t exercise much at all. Researchers found that the members in their group carrying the e4 gene who did not exercise had significant atrophy of their hippocampus. It had shrunk by about 3 percent, on average. The volunteers who carried the e4 gene but exercised regularly showed no shrinkage of their hippocampus, as did the other volunteers that did not carry this e4 gene who did exercise. When scanned, the brains of the physically active volunteers at high risk for Alzheimer’s disease looked just like the brains of people at much lower risk for the disease, stated Stephen M. Rao, a professor at the Cleveland Clinic, who oversaw the study. Exercise had suggested to have been very helpful for those with Alzheimer’s. As for the others who didn’t exercise regularly they seemed to be slipping, structurally, toward dysfunction. Dr. Rao stated although the e4 gene is known to alter fat metabolism within the brain, as does exercise, exercise could be counteracting with some of the effects of the e4 gene.
More studies still need to be done to better understand Alzheimer's disease. But these scans of the volunteers’ brains who did and didn’t exercise were significantly different, that proved something right? It’s astounding how much exercise really “does a body good.” Any kind of moderate physical activity daily helps you feel younger, have more energy, and on the outside you physically look younger. The more internal benefits of exercise is preventing heart disease, diabetes, and hopefully Alzheimer's. I don’t know of a reason to not exercise?